Critical Errors in PubChem Document, Reference Number 481108204, Anhydrous Dextrose (Compound)

My May 14, 2025, Email to: info@ncbi.nlm.nih,gov

 

As you are aware, dextrose anhydrous is the dry form of corn sugar manufactured in a laboratory from cornstarch, D-GLUCOSE, 21CFR184.1857. Therefore, it is impossible for dextrose to be produced by the human liver, or to be “naturally present” in ANY living organism.

 

There are nearly 20K world-wide members in corn allergy support groups, and their personal testimonies addressing dextrose are terrifying, since clinicians are telling corn-allergic patients: “Dextrose is naturally present in humans.”  As a result, we are required to advise clinicians that:

 

1.    They can be sued for medical malpractice if they inject dextrose (cornstarch sugar/D-glucose) into a corn-allergic patient in direct violation of the contraindication warning in the package insert.

2.    We are required to instruct clinicians to read the contraindication warning in the package insert.  This should NOT be our responsibility to guarantee our safety.

3.    We are also required to advise clinicians that administering dextrose (cornstarch sugar/D-glucose)-containing IV fluids to a corn-allergic patient is equivalent to administering penicillin to a patient with an allergy to penicillin. This critical medical error is subject to reporting and disclosure.
https://www.ncbi.nlm.nih.gov/books/NBK2652/

 

 

Therefore, we would appreciate your cooperation in amending this PubChem document for the safety of corn-allergic consumers and patients. 
https://pubchem.ncbi.nlm.nih.gov/compound/DEXTROSE

Corn-allergic patients will no longer tolerate clinicians telling us: “Dextrose is naturally present in humans.”


Sincerely,

Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/

 

 

DOCUMENTATION:

 

Corn Sugar Hearings, Sixty-Ninth Congress, January 27, 1926
". . . that corn sugar is what is chemically known as dextrose . . ." [emphasis added]
https://babel.hathitrust.org/cgi/pt?id=umn.31951d03669822a&view=1up&seq=3&skin=2021

 

Published in a Medical Journal:
"Dextrose-containing solutions pose a significant risk to patients allergic to corn. Dextrose used for IV fluids is prepared by . . . hydrolysis of cornstarch."
https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/05000/Excipients_in_Anesthesia_Medications.11.aspx

 

Conversion of Corn to Dextrose:
"Corn must first be converted to corn sugar (dextrose, the common commercial name for D-glucose) . . ." [emphasis added]
https://polymerinnovationblog.com/from-corn-to-poly-lactic-acid-pla-fermentation-in-action/

 

Baxter Healthcare Corporation
LACTATED RINGERS AND DEXTROSE- sodium chloride, sodium lactate, potassium chloride, calcium chloride and dextrose monohydrate injection, solution 

DESCRIPTION
"Dextrose is derived from corn." [emphasis added]
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6acc9f96-7088-45a7-b48f-1a861e3467ab

 

Millipore Sigma
"Dextrose
Biological Source: Corn" [emphasis added]
https://www.sigmaaldrich.com/US/en/substance/dextrose1801650997

 

Code of Federal Regulation 21CFR184.1857(a)

“Corn sugar . . . commonly called D-glucose or dextrose, [emphasis added] is the chemical α-D-glucopyranose. It occurs as the anhydrous or the monohydrate form and is produced by the complete hydrolysis of corn starch [emphasis added] with safe and suitable acids or enzymes, followed by refinement and crystallization from the resulting hydrolysate.
https://www.ecfr.gov/current/title-21/chapter-I/subchapter-B/part-184/subpart-B/section-184.1857

 

The European Medicines Agency also confirms dextrose is only derived from corn.
"Dextrose a sugar that is obtained from corn starch" [emphasis added]
https://www.ema.europa.eu/en/documents/scientific-guideline/draft-information-package-leaflet-regarding-dextrans-used-excipients-medicinal-products-human-use_en.pdf

 

Corn Refiners Association
"Intravenous Solution
Patients with low blood sugar are often given IV drips, many of which contain dextrose, a corn derivative." [emphasis added]
https://corn.org/products/sweeteners/

 

Nutritive Sweeteners From Corn, Corn Refiners Association
Dextrose is referenced 9 times in this article. It is IMPOSSIBLE for a manufactured corn-derived sweetener to be naturally present in ANY living organism.
https://corn.org/wp-content/uploads/2018/10/NSFC2006.pdf

 

"Pharmacists are requested to use caution and be aware that many drugs and medications contain undisclosed potential allergens in the form of sugars, starches, and celluloses. Share the corn allergy example with prescribers . . ." [emphasis added]
http://library.bcpharmacists.org/6_Resources/6-7_ReadLinks/ReadLinks-MayJun2007.pdf

 

Golisano Children's Hospital
"Corn-Free Diet" [emphasis added]
“Cornstarch, corn syrup, high fructose corn syrup, dextrins, dextrose, etc.”
https://www.urmc.rochester.edu/childrens-hospital/nutrition/corn-free.aspx

 

MICHAEL C. JUNGKEIT, M.D.
"INGREDIENTS TO AVOID CORN ALLERGY" [emphasis added]
Corn starch, Corn sweetener, corn sugar, Corn syrup, corn syrup solids, Dextrin, Dextrose (also found in IV solutions), Dextrose anything . . ."
https://www.northkitsapent.com/wp-content/uploads/2016/02/FoodallergiesCORN.pdf

 

Corn Products Refining Co., Life Magazine, 8 September 1941
"Dextrose: All-American Corn Sugar . . .  derived from American corn, refined in American factories, distributed by American companies.” [emphasis added\]
https://candyprofessor.wordpress.com/2010/09/29/dextrose-all-american-corn-sugar/

 

 NIH National Library of Medicine
“Probable anaphylactic reaction to corn-derived dextrose solution” [emphasis added]

[Note: Since dextrose is ONLY manufactured from cornstarch, the modifier “corn-derived” is not required.]
https://pubmed.ncbi.nlm.nih.gov/1808842/

 

 

Glucose is the lifeblood of every living organism essential for their survival.  Glucose (natural blood sugar) CANNOT also be utilized as a glucose (blood sugar)-elevating agent.  D-glucose (cornstarch sugar/dextrose) was then developed from cornstarch for this purpose; however, since hospitals ONLY stock glucose (blood sugar)-elevating agents from corn, there is currently NO PROTOCOL for treating hypoglycemic corn-allergic patients.
 

What is glucose?
https://medlineplus.gov/bloodglucose.html

 

As you are aware, glucose (blood sugar)-elevating tablets contain added corn-derived excipients; e.g., dextrose, that can PROVE FATAL to corn-allergic consumers/patients.

There is NO PROTOCOL for treating hypoglycemic corn-allergic patients.
[My personal testimony.]
https://cornallergyadvocacyresources.blogspot.com/2024/07/there-is-no-protocol-for-treating.html

Physiology of Glucose (natural blood sugar), Molecular Formula C6H12O6, a monosaccharide
If this molecular formula is applied to ANY cornstarch-derived formulations (polysaccharides), the publication is FRAUDULENT.
https://www.ncbi.nlm.nih.gov/books/NBK545201/

 

GLUCOSE: Blood sugar naturally present in every living organism essential for their survival; i.e., their lifeblood.

D-GLUCOSE: Synthetic, laboratory-manufactured from CORNSTARCH (dextrose/corn sugar).

L-GLUCOSE:  Synthetic, laboratory-manufactured formulation from D-glucose.

 

 

GLUCOSE: Monosaccharide (natural; i.e., not manufactured)

D-GLUCOSE: Polysaccharide (produced from starch)

L-GLUCOSE: Polysaccharide (produced from

 

WHAT IS STARCH?
Polysaccharide, molecular formula (C6H10O5)n.
https://byjus.com/chemistry/starch/#:~:text=The%20chemical%20formula%20of%20the,help%20plants%20in%20storing%20energy.


DEXTROSE MONOHYDRATE: The liquid form of corn sugar produced from cornstarch/D-glucose.

DEXTROSE ANHYDROUS: The dry form of corn sugar produced from cornstarch/D-glucose.

 

The moment that natural glucose, C6H12O6, is manipulated into another formulation, it can no longer be classified as "glucose." D-glucose and L-glucose are the synthetic, laboratory-manufactured formulations; therefore, they cannot be "biochemically identical" to glucose.

 

Look at glucose (natural blood sugar) and the synthetic formulations (D-glucose and L-glucose) in a "family tree format."  Glucose (natural blood sugar) is at the top of the family tree, with the synthetic formulations under glucose. They cannot be "biochemically identical at the molecular level.”

 

Dr. Gilbert V. Levin clearly understood the difference between glucose (natural), D-glucose (synthetic; enantiomer of L-glucose; isomer of glucose), and L-glucose (synthetic; enantiomer of D-glucose; isomer of glucose).
https://spinoff.nasa.gov/Spinoff2004/ch_4.html