Tuesday, December 14, 2021

My December 14, 2021, Email to the Board of Trustees, American Medical Association (AMA) Re: Dextrose (Corn Sugar) / Conflicting Molecular Formulas

To:  Board of Trustees, American Medical Association (AMA)

Gerald.Harmon@ama-assn.org
Jack.Resneck@ama-assn.org
Susan.Bailey@ama-assn.org
Bruce.Scott@ama-assn.org
Ilsa.egbert@ama-assn.org
Bobby.Mukkamala@ama-assn.org
Sandra.Fryhofer@ama-assn.org
Russ.Kridel@ama-assn.org
Scott.Ferguson@ama-assn.org
David.Aizuss@ama-assn.org
Madelyn.Butler@ama-assn.org
Willarda.Edwards@ama-assn.org
Jesse.Ehrenfeld@ama-assn.org
Drayton.Harvey@ama-assn.org
Pratistha.Koirala@ama-assn.org
Ilse.Levin@ama-assn.org
Thomas.Madejski@ama-assn.org
Mario.Motta@ama-assn.org
Harris.Pastides@ama-assn.org
Michael.Suk@ama-assn.org
Willie.Underwood@ama-assn.org
https://www.ama-assn.org/about/board-trustees/board-trustees-members


Re:  Dextrose (Corn Sugar/D-Glucose) / Conflicting Molecular Formulas


As distinguished physicians, you are all aware that the reason corn sugar (dextrose/D-glucose)-containing IV fluids are contraindicated for administration to corn-allergic patients in the package insert is due to the fact that corn sugar is produced from cornstarch, 21CFR184.1857; and cornstarch contains allergenic corn proteins, which can prove fatal to anyone with an IgE-mediated allergy to corn.  You are also aware that clinicians can be sued for medical malpractice for administering corn sugar (dextrose/D-glucose)-containing IV fluids to corn-allergic patients in direct violation of this contraindication warning, which is equivalent to administering penicillin to a patient with an allergy to penicillin.


We believe the reason many clinicians are endangering the lives of corn-allergic patients by telling them: "You cannot be allergic to dextrose, since dextrose is naturally present in humans," is due to the American Medical Association equating corn sugar (dextrose/D-glucose) with blood sugar naturally present in all living organisms (glucose) in their "Glossary of Medical Terms."  Please provide us with your source for this claim.


"Dextrose- another name for the sugar glucose" [the source reference is not viable]
http://file.lacounty.gov/SDSInter/dmh/159358_AMAGlossaryofMedicalTerms_Ver1.0.pdf


Code of Federal Regulation, 21CFR184.1857, Corn Sugar (Dextrose/D-Glucose)

Glucose is sugar.  If it is manufactured from cornstarch, it is classified as D-glucose/dextrose vs. glucose (blood sugar) that is naturally present in all living organisms.   

Glucose: blood sugar essential for survival of all living organisms

D-Glucose: laboratory-created form of sugar produced from cornstarch (dextrose)
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

L-Glucose: laboratory-created form of sugar



Conflicting Molecular Formulas


We have been in contact with the FDA and the National Library of Medicine, since it is clearly apparent the incorrect molecular formula has been applied to 21CFR184.1857. The correct molecular formula should be C6H14O7, not C6H12O6.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857


Google search:  Sugar, corn molecular formula
MF = C6H14O7

High Fructose Corn Syrup, Molecular Formula C6H14O7


Entry Terms:


Isoglucose, C6H14O7
Maize Syrup, C6H14O7
Syrup, Maize, C6H14O7
Glucose-Fructose Syrup, C6H14O7
Glucose Fructose Syrup, C6H14O7
Syrup, Glucose-Fructose, C6H12O6
Corn Sugar, C6H12O6
Sugar, Corn, C6H14O7
High-Fructose Maize Syrup, C6H14O7
High Fructose Maize Syrup, C6H14O7
Maize Syrup, High-Fructose, C6H14O7
Syrup, High-Fructose Maize, C6H14O7
https://www.ncbi.nlm.nih.gov/mesh/68066248


Note the following conflicting molecular formulas in this list:

Glucose Fructose Syrup, C6H14O7
Syrup, Glucose-Fructose, C6H12O6
Corn Sugar, C6H12O6
Sugar, Corn, C6H14O7

 

 

I have been a full-time corn allergy advocate for nearly eight years; and in my effort to protect the lives of corn-allergic patients, I have distributed the following blog post globally (including global media).  We are requesting the immediate correction of the definition the AMA has applied to dextrose which is, in fact, corn sugar produced from allergenic cornstarch/D-glucose; and can prove fatal to anyone with an IgE-mediated allergy to corn.  

 

The American Medical Association (AMA) is intentionally endangering the lives of corn-allergic citizens, and exposing clinicians to potential liability. [Documented]
DEXTROSE IS CORN SUGAR!

https://cornallergyadvocacyresources.blogspot.com/2021/12/the-american-medical-association-ama-is.html

 

 

On behalf of corn-allergic citizens, we would appreciate your immediate attention to this critical concern.  

 

Respectfully,

 

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

 

Additional Reference:

My December 3, 2021, Email to the National Library of Medicine/FDA/PDR Re: Revision of PubChem CID 22814120 (Dextrose Monohydrate)
https://cornallergyadvocacyresources.blogspot.com/2021/12/my-december-3-2021-email-to-national.html


Addendum:

 

High Fructose Corn Syrup, Molecular Formula C6H14O7*

Entry Terms:


Isoglucose, C6H14O7
Maize Syrup, C6H14O7
Syrup, Maize, C6H14O7
Glucose-Fructose Syrup, C6H14O7
Glucose Fructose Syrup, C6H14O7
Syrup, Glucose-Fructose, C6H12O6
Corn Sugar, C6H12O6
Sugar, Corn, C6H14O7
High-Fructose Maize Syrup, C6H14O7
High Fructose Maize Syrup, C6H14O7
Maize Syrup, High-Fructose, C6H14O7
Syrup, High-Fructose Maize, C6H14O7
https://www.ncbi.nlm.nih.gov/mesh/68066248

 

*This is exactly how this list appeared on this website within the last month (copied directly from the website).  After I contacted the National Library of Medicine, the corresponding molecular formulas were removed; however, they are clearly noted on the corresponding PubChem documents.

 

 

Blog Post Reference:

My December 14, 2021, Email to the Board of Trustees, American Medical Association (AMA) Re: Dextrose (Corn Sugar) / Conflicting Molecular Formulas
https://cornallergyadvocacyresources.blogspot.com/2021/12/my-december-14-2021-email-to-board-of.html

 

 

 

 

Thursday, December 9, 2021

The American Medical Association (AMA) is intentionally endangering the lives of corn-allergic citizens, and exposing clinicians to potential liability. [Documented]

Based on the description of their organization, it is incomprehensible that the American Medical Association would intentionally endanger patients' lives, and expose clinicians to potential liability.


"Founded in 1847, the American Medical Association (AMA) is the largest and only national association that convenes 190+ state and specialty medical societies and other critical stakeholders. Throughout history, the AMA has always followed its mission: to promote the art and science of medicine and the betterment of public health.


As the physicians’ powerful ally in patient care, the AMA delivers on this mission by representing physicians with a unified voice in courts and legislative bodies across the nation, removing obstacles that interfere with patient care, leading the charge to prevent chronic disease and confront public health crises, and driving the future of medicine to tackle the biggest challenges in health care and training the leaders of tomorrow.


The AMA’s system of governance and policy making include the board of trustees, House of Delegates, executive vice president, councils and committees, special sections, and AMA senior leadership and staff."
https://www.ama-assn.org/about


Documented Evidence:


"Dextrose- another name for the sugar glucose" [the source reference is not viable]
http://file.lacounty.gov/SDSInter/dmh/159358_AMAGlossaryofMedicalTerms_Ver1.0.pdf


Based on testimonies from the 15K+ members in corn allergy support groups, many clinicians continue to endanger the lives of corn-allergic patients by stating that: "You cannot be allergic to dextrose, since dextrose is naturally present in our bodies."


The American Medical Association is egregiously equating corn sugar produced from cornstarch (dextrose/D-glucose) with blood sugar naturally present in all living organisms (glucose).


Corn-allergic patients will no longer tolerate this blatant deception, which intentionally endangers our lives.


Documentation:


Dextrose is the chemical name for corn sugar manufactured from cornstarch/D-glucose, 21CFR184.1857, which can prove fatal to anyone with an IgE-mediated allergy to corn.
https://cornallergyadvocacyresources.blogspot.com/2021/06/dextrose-is-corn-sugar-21cfr1841857-and.html


If "Dextrose" is referenced on the FDA’s Food Additive Status List, it refers to 21CFR184.1857.
https://www.fda.gov/food/food-additives-petitions/food-additive-status-list#ftnD


If 21CFR184.1857 is referenced, the definition is “Corn sugar” a/k/a dextrose/D-glucose

Sec. 184.1857 Corn sugar. 

(a) Corn sugar . . . commonly called D-glucose or dextrose, is the chemical [alpha]-D-glucopyranose. It occurs as the anhydrous or the monohydrate form and is produced by the complete hydrolysis of corn starch [sic] with safe and suitable acids or enzymes, followed by refinement and crystallization from the resulting hydrolysate.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857


...called corn sugar...the name for the sweetener dextrose...used by people who have trouble tolerating regular sugar for 30 years, the FDA says.
https://www.npr.org/sections/thesalt/2012/05/30/154009682/fda-rules-corn-syrup-cant-change-its-name-to-corn-sugar


Nutritive Sweeteners From Corn, Corn Refiners Association, 2006
https://corn.org/wp-content/uploads/2018/10/NSFC2006.pdf


The Corn Products Refining Company advertised dextrose as corn sugar in the 1940s. 

“Dextrose: All-American Corn Sugar,” Candy Professor, September 29, 2010
https://candyprofessor.wordpress.com/2010/09/29/dextrose-all-american-corn-sugar/


Corn must first be converted to corn sugar (dextrose, the common commercial name for D-glucose) . . .
https://polymerinnovationblog.com/from-corn-to-poly-lactic-acid-pla-fermentation-in-action/


Dextrose is the chemical name for corn sugar manufactured from allergenic cornstarch; therefore, dextrose cannot be "naturally present" in mammals, fruits, honey, etc.

Corn Sugar Hearings, Sixty-Ninth Congress, January 27, 1926
. . . that corn sugar is what is chemically known as dextrose . . .
https://babel.hathitrust.org/cgi/pt?id=umn.31951d03669822a&view=1up&seq=3


The American Medical Association is Exposing Clinicians to Potential Liability


Clinicians can be sued for medical malpractice for administering corn sugar (dextrose/D-glucose)-containing IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert. Administering corn sugar (dextrose/D-glucose)-containing IV fluids to corn-allergic patients is a critical medical error equivalent to administering penicillin to a patient with an allergy to penicillin.  This medical error is subject to reporting and disclosure.


Solutions containing dextrose should be used with caution, if at all, in patients with known allergy to corn or corn products.
D-Glucopyranose monohydrate
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf


Dextrose-containing solutions pose a significant risk to patients allergic to corn. Dextrose used for IV fluids is prepared by the simple hydrolysis of cornstarch.
Burbridge, Mark A. MD; Jaffe, Richard A. MD, PhD Excipients in Anesthesia Medications, Anesthesia & Analgesia: May 2019 - Volume 128 - Issue 5 - p 891-900 doi: 10.1213/ANE.0000000000003302
https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/05000/Excipients_in_Anesthesia_Medications.11.aspx


College of Pharmacists of British Columbia, "Warning: corn-related allergens . . ."

Pharmacists are requested to use caution and be aware that many drugs and medications contain undisclosed potential allergens in the form of sugars, starches, and celluloses. Share the corn allergy example with prescribers, so they are aware of potential allergic reactions patients may face. This relatively unknown but potentially serious allergy highlights the need for pharmacists and other health-care professionals to be involved in ADR reporting.
http://library.bcpharmacists.org/6_Resources/6-7_ReadLinks/ReadLinks-MayJun2007.pdf


Chapter 35 Error Reporting and Disclosure
https://www.ncbi.nlm.nih.gov/books/NBK2652/


Corn-allergic patients should not be responsible for educating our clinicians in an effort to guarantee our safety.


Guidelines for reporting clinicians who administer corn sugar (dextrose/D-glucose)-containing IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert.
https://cornallergyadvocacyresources.blogspot.com/2019/12/lactated-ringers-in-5-dextrose.html


For the safety of corn-allergic patients, we are demanding the immediate correction of the definition for dextrose (corn sugar/D-glucose) by the American Medical Association.  

 

 

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

 

Additional Reference:

My December 14, 2021, Email to the Board of Trustees, American Medical Association (AMA) Re: Dextrose (Corn Sugar) / Conflicting Molecular Formulas
https://cornallergyadvocacyresources.blogspot.com/2021/12/my-december-14-2021-email-to-board-of.html




Blog Post Reference: 

The American Medical Association (AMA) is intentionally endangering the lives of corn-allergic citizens, and is exposing clinicians to potential liability.  [Documented]
https://cornallergyadvocacyresources.blogspot.com/2021/12/the-american-medical-association-ama-is.html


Friday, December 3, 2021

My December 3, 2021, Email to the National Library of Medicine/FDA/PDR Re: Revision of PubChem CID 22814120 (Dextrose Monohydrate)

 Urgent Correction Required:  PubChem CID 22814120

 

Based on testimonies from the 15K+ members in corn allergy support groups, many clinicians continue to endanger the lives of corn-allergic patients by stating that: "You can't be allergic to dextrose, since dextrose is naturally present in our bodies."


Dextrose is corn sugar produced from allergenic cornstarch/D-glucose, the chemical [alpha]-D-glucopyranose. 21CFR184.1857, which can prove fatal to anyone with an IgE-mediated allergy to corn.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857


Source of this misinformation: 

PubChem CID 22814120

"A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state." [FALSE]
https://pubchem.ncbi.nlm.nih.gov/compound/22814120


Glucose is blood sugar naturally present in all living organisms, and is essential for their survival.  

D-glucose is a manufactured, food-derived sugar from cornstarch (dextrose), 21CFR184.1857..

 

Therefore, glucose (blood sugar) and D-glucose (corn sugar/dextrose) cannot be “biochemically identical.”  They may be mirror images of each other (enantiomers); however, like a glove, if you place your hands on top of each other, they are not identical.  Likewise, you cannot fit your right hand into a left-handed glove. 

 

Many clinicians and academics are falsely claiming that glucose is not the blood sugar that is naturally present in all living organisms. They are falsely claiming that D-glucose (corn sugar/dextrose) is naturally present in all living organisms.  In addition, they have also falsely declared that : "Dextrose is naturally present in humans."
[Documented evidence on file.]


Since corn sugar (dextrose/D-glucose) is often utilized as a glucose (blood sugar)-elevating agent, the following statement in PubChem CID 22814120 is correct.


"It is used therapeutically in fluid and nutrient replacement."
https://pubchem.ncbi.nlm.nih.gov/compound/22814120


Protect clinicians from potential malpractice lawsuits: 

Clinicians can be sued for medical malpractice for administering corn sugar (dextrose/D-glucose)-containing IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert; therefore, your immediate attention to this issue is required. 

 

Documentation:

Lactated Ringer’s and 5% Dextrose Injection
D-Glucopyranose monohydrate
Dextrose is derived from corn.
https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/016679s114lbl.pdf

 

Solutions containing dextrose should be used with caution, if at all, in patients with known allergy to corn or corn products.  - Page 3
D-Glucopyranose monohydrate
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf

 

Dextrose-containing solutions pose a significant risk to patients allergic to corn. Dextrose used for IV fluids is prepared by the simple hydrolysis of cornstarch.

Burbridge, Mark A. MD; Jaffe, Richard A. MD, PhD Excipients in Anesthesia Medications, Anesthesia & Analgesia: May 2019 - Volume 128 - Issue 5 - p 891-900 doi: 10.1213/ANE.0000000000003302
https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/05000/Excipients_in_Anesthesia_Medications.11.aspx

 

BCPharmacists, "Warning: corn-related allergens . . ."

Pharmacists are requested to use caution and be aware that many drugs and medications contain undisclosed potential allergens in the form of sugars, starches, and celluloses. Share the corn allergy example with prescribers, so they are aware of potential allergic reactions patients may face. This relatively unknown but potentially serious allergy highlights the need for pharmacists and other health-care professionals to be involved in ADR reporting.
http://library.bcpharmacists.org/6_Resources/6-7_ReadLinks/ReadLinks-MayJun2007.pdf

 

If "Dextrose" is referenced on the FDA’s Food Additive Status List, it refers to 21CFR184.1857.
https://www.fda.gov/food/food-additives-petitions/food-additive-status-list#ftnD


If 21CFR184.1857 is referenced, the definition is “Corn sugar.”

Sec. 184.1857 Corn sugar.

(a) Corn sugar . . . commonly called D-glucose or dextrose, is the chemical [alpha]-D-glucopyranose. It occurs as the anhydrous or the monohydrate form and is produced by the complete hydrolysis of corn starch [sic] with safe and suitable acids or enzymes, followed by refinement and crystallization from the resulting hydrolysate.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

 

"...called corn sugar...the name for the sweetener dextrose...used by people who have trouble tolerating regular sugar for 30 years, the FDA says."
https://www.npr.org/sections/thesalt/2012/05/30/154009682/fda-rules-corn-syrup-cant-change-its-name-to-corn-sugar

 

Nutritive Sweeteners From Corn, Corn Refiners Association, 2006
https://corn.org/wp-content/uploads/2018/10/NSFC2006.pdf

 

The Corn Products Refining Company declared dextrose to be corn sugar back in the 1940s.

“Dextrose: All-American Corn Sugar,” Candy Professor, September 29, 2010
https://candyprofessor.wordpress.com/2010/09/29/dextrose-all-american-corn-sugar/

 

"Corn must first be converted to corn sugar (dextrose, the common commercial name for D-glucose) . . ." [emphasis added]
https://polymerinnovationblog.com/from-corn-to-poly-lactic-acid-pla-fermentation-in-action/

 

 

IMPORTANT FACT: 

Since dextrose is corn sugar produced from cornstarch/D-glucose, it is impossible for dextrose (corn sugar) to be naturally present in, or to be derived from, any source other than corn; e.g., dextrose (corn sugar) is not naturally present in grapes, nor can dextrose (corn sugar) be derived from grapes.

 

URGENT APPEAL:

Corn-allergic patients will no longer tolerate our clinicians telling us: "You can't be allergic to dextrose, since dextrose is naturally present in our bodies."


Therefore, we are appealing to United States government agencies to protect the lives of corn-allergic citizens by recognizing that dextrose is corn sugar produced from allergenic cornstarch (D-glucose), pursuant to Code of Federal Regulation 21CFR184.1857, which can prove fatal to anyone with an IgE-mediated allergy to corn.

 

PubChem CID 22814120 requires immediate correction to reflect the facts as presented.
https://pubchem.ncbi.nlm.nih.gov/compound/22814120

 

 

In summary, corn-allergic patients should not be required to educate our clinicians to guarantee our safety. 

 

 

 

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

 

Additional References:

 

Dextrose is the chemical name for corn sugar manufactured from cornstarch/D-glucose, 21CFR184.1857, which can prove fatal to anyone with an IgE-mediated allergy to corn.
https://cornallergyadvocacyresources.blogspot.com/2021/06/dextrose-is-corn-sugar-21cfr1841857-and.html

 

Guidelines for reporting clinicians who administer corn sugar (dextrose/D-glucose)-containing IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert.
https://cornallergyadvocacyresources.blogspot.com/2019/12/lactated-ringers-in-5-dextrose.html

 



Blog Post Reference:
 

My December 3, 2021, Email to the National Library of Medicine/FDA/PDR Re: Revision of PubChem CID 22814120 (Dextrose Monohydrate)
https://cornallergyadvocacyresources.blogspot.com/2021/12/my-december-3-2021-email-to-national.html


Saturday, July 24, 2021

Archer Daniels Midland Company (ADM) is intentionally endangering the lives of corn-allergic citizens [Documented]

Since Archer Daniels Midland Company (ADM) has not corrected the misinformation on their website that I detailed in my June 2, 2021, email to them, it is apparent that ADM is intentionally endangering the lives of corn-allergic citizens. 

Excerpt from my email to ADM: 

Re:  Discrepancies on your website that endanger the lives of corn-allergic consumers and patients.

Correct:
"Dextrose from ADM, a . . . sweetener made from corn . . ."
"Energy source: supplies efficient, energy-maintaining fuel for foods, beverages and supplements"
https://www.adm.com/products-services/food/sweetening-solutions/dextrose

Incorrect:
Dextrose: The Can-Do Sweetener
"Dextrose (also known as D-glucose) is a simple sugar that comes from corn, wheat and other natural sources, like fruits and honey." [FALSE]
"Since dextrose is the body’s primary source of energy, [FALSE] the medical industry uses dextrose in a range of applications . . ."
https://assets.adm.com/Products-And-Services/Food-Ingredients/SparkHub/Sweeteners/Dextrose_Sell_Sheet.pdf

Archer Daniels Midland (ADM) is clearly aware that the only source of dextrose is corn.

Dextrose is corn sugar, 21CFR184.1857, and can prove fatal to anyone with an IgE-mediated allergy to corn.
https://cornallergyadvocacyresources.blogspot.com/2021/06/dextrose-is-corn-sugar-21cfr1841857-and.html 


We are requesting the immediate correction of the misinformation on their website for the protection of corn-allergic citizens. 

 

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

Reference:

My June 2, 2021 Email to ADM, sweeteners@adm.com, Re: Dextrose (Corn Sugar)
https://cornallergyadvocacyresources.blogspot.com/2021/06/my-june-2-2021-email-to-adm-re-dextrose.html

 


Blog Post Reference:

Archer Daniels Midland Company (ADM) is intentionally endangering the lives of corn-allergic citizens [Documented]
https://cornallergyadvocacyresources.blogspot.com/2021/07/archer-daniels-midland-company-adm-is.html


 

Wednesday, June 30, 2021

The FDA’s June 30, 2021, reply to my June 28, 2021, email requesting their contact telephone number to provide to our clinicians verifying that dextrose is corn sugar

To:  FDA's Division of Drug Information, Center for Drug Evaluation and Research (CDER), druginfo@fda.hhs.gov

Date:  June 28, 2021

“Corn-allergic citizens should not be required to provide documentation to our clinicians that dextrose (corn sugar) is
NOT "naturally present" in mammals, and dextrose-containing IV fluids can prove fatal to anyone with an IgE-mediated allergy to corn. 

I had surgery two weeks ago, and had to convince my surgeon that dextrose is corn sugar.  She originally told me that "dextrose is glucose."  However, the admitting nurse told me on the morning of my surgery that "dextrose is naturally present in humans."  She refused to review the documentation I brought with me prior to my surgery. Thankfully, dextrose-containing IV fluids were not administered to me during my hospitalization. 

This continues to be a major complaint by the nearly 15K members in our corn allergy support groups.  Therefore, we need to provide our clinicians with an FDA telephone number to call to verify that dextrose is corn sugar, and that dextrose is NOT "naturally present" in humans. 

Please provide us with an FDA emergency contact number to give to our clinicians to verify these facts. 

Thank you very much on behalf of corn-allergic citizens.”

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

 

June 30, 2021, reply to my email from Lindsay, Pharmacist, CDER

"Dear Diane H.,

Thank you for writing the Division of Drug Information, in the FDA’s Center for Drug Evaluation and Research.

We are so sorry to learn that this happened and hope that your surgery went well. For drug information that is accessible 24/7, FDA offers prescribing information for FDA-approved drug products in the online databases Drugs@FDA [https://www.accessdata.fda.gov/scripts/cder/daf/] as well as https://labels.fda.gov/.  FDA does not offer emergency after-hours drug information services by phone. Our hours are Monday-Friday 8 am-4:30 pm except federal holidays. During those hours our drug information specialists can be reached at 855-543-3784 or 301-796-3400.

We agree that you should not have to fight to be heard as a patient. [emphasis added]  While the FDA does not regulate the practice of medicine or nursing, if you have not done so already, you may wish to submit a complaint to the State Medical Board for your surgeon and State Nursing Board for your admitting surgical nurse. Contact information for your state may be found from the Federation of State Medical Boards [https://www.fsmb.org/contact-a-state-medical-board/]  and National Council of State Boards of Nursing [https://www.ncsbn.org/contact-bon.htm].”

Best regards,

Lindsay
Pharmacist
Division of Drug Information
Center for Drug Evaluation and Research
Tel: 855-543-DRUG (855-543-3784)
druginfo@fda.hhs.gov

 

Additional Resources/Documentation to Provide to Clinicians:

Dextrose is corn sugar, 21CFR184.1857, and can prove fatal to anyone with an IgE-mediated allergy to corn.
https://cornallergyadvocacyresources.blogspot.com/2021/06/dextrose-is-corn-sugar-21cfr1841857-and.html

Dextrose (Corn Sugar/D-Glucose) IV Solutions Contraindicated for Corn-Allergic Patients
https://cornallergyadvocacyresources.blogspot.com/2020/08/corn-sugar-dextrose-iv-fluids.html

Administering dextrose-containing IV fluids to corn-allergic patients is a critical medical error equivalent to administering penicillin to patients with an allergy to penicillin.  Guidelines for reporting medical professionals who administer corn sugar (dextrose/D-glucose) IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert.
https://cornallergyadvocacyresources.blogspot.com/2019/12/lactated-ringers-in-5-dextrose.html



Blog Post Reference:

The FDA’s June 30, 2021, reply to my June 28, 2021, email requesting their contact telephone number to provide to our clinicians verifying that dextrose is corn sugar
https://cornallergyadvocacyresources.blogspot.com/2021/06/the-fdas-june-30-2021-reply-to-my-june.html

 


Friday, June 11, 2021

Dextrose is corn sugar, 21CFR184.1857, and can prove fatal to anyone with an IgE-mediated allergy to corn.

[Please refer to June 15, 2021, June 30, 2021, and July 3, 2021, critical updates at the end of this blog post.]


Dextrose (corn sugar manufactured from cornstarch/D-glucose) is an FDA-approved “food additive” that is generally recognized as safe (GRAS); therefore, dextrose cannot be naturally present in the human body or in any other food product.  It is ONLY derived from corn.

Glucose is blood sugar naturally present in all living organisms, and is essential for their survival.  D-glucose is a manufactured, food-derived sugar from cornstarch (dextrose).  Therefore, glucose (blood sugar) and D-glucose (corn sugar/dextrose) cannot be “biochemically identical.”  They may be mirror images of each other (enantiomers); however, like a glove, if you place your hands on top of each other, they are not identical.  Likewise, you cannot fit your right hand into a left-handed glove.  


If you reference “Dextrose” on the FDA’s Food Additive Status List, it refers to 21CFR184.1857.
https://www.fda.gov/food/food-additives-petitions/food-additive-status-list#ftnD

If you reference 21CFR184.1857, the definition is “Corn sugar.”
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

"...called corn sugar...the name for the sweetener dextrose...used by people who have trouble tolerating regular sugar for 30 years, the FDA says."
https://www.npr.org/sections/thesalt/2012/05/30/154009682/fda-rules-corn-syrup-cant-change-its-name-to-corn-sugar

The Corn Refiners Association correctly identifies corn-derived sweeteners with the requisite “D-“ modifier (DE for dextrose equivalent).  This critical modifier has been omitted from many published articles over many decades, which is the reason that corn-derived sweeteners are being erroneously equated with blood sugar (glucose). 

Nutritive Sweeteners From Corn, Corn Refiners Association, 2006
https://corn.org/wp-content/uploads/2018/10/NSFC2006.pdf

The Corn Products Refining Company declared dextrose to be corn sugar back in the 1940s.

“Dextrose: All-American Corn Sugar,” Candy Professor, September 29, 2010
https://candyprofessor.wordpress.com/2010/09/29/dextrose-all-american-corn-sugar/

"Corn must first be converted to corn sugar (dextrose, the common commercial name for D-glucose) . . ."
https://polymerinnovationblog.com/from-corn-to-poly-lactic-acid-pla-fermentation-in-action/

Dextrose is the chemical name for corn sugar manufactured from allergenic cornstarch; therefore, dextrose cannot be "naturally present" in mammals, fruits, honey, etc. 
". . . that corn sugar is what is chemically known as dextrose, . . ."
https://babel.hathitrust.org/cgi/pt?id=umn.31951d03669822a&view=1up&seq=3


Dextrose (corn sugar/D-glucose)-containing IV solutions are contraindicated for administration to corn-allergic patients in the package insert.

Administering dextrose (corn sugar/D-glucose)-containing IV fluids to corn-allergic patients is a critical medical error equivalent to administering penicillin to a patient with an allergy to penicillin.

Dextrose (Corn Sugar/D-Glucose) IV Solutions Contraindicated for Corn-Allergic Patients
https://cornallergyadvocacyresources.blogspot.com/2020/08/corn-sugar-dextrose-iv-fluids.html

Lactated Ringer’s in 5% Dextrose Contraindicated for Corn-Allergic Patients
[Includes guidelines for reporting clinicians who administer dextrose-containing IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert.]
https://cornallergyadvocacyresources.blogspot.com/2019/12/lactated-ringers-in-5-dextrose.html

“DEXTROSE or refined corn sugar . . . This is the form of dextrose used for intravenous injections and in various pharmaceutical and medicinal preparations.”
https://ajph.aphapublications.org/doi/pdf/10.2105/AJPH.29.2.135

Anaphylactoid reaction to 50% solution of dextrose
Czarny D, Prichard PJ, Fennessy M, Lewis S. Anaphylactoid reaction to 50% solution of dextrose. Med J Aust. 1980 Sep 6;2(5):255-8. doi: 10.5694/j.1326-5377.1980.tb131845.x. PMID: 6159523
https://onlinelibrary.wiley.com/doi/abs/10.5694/j.1326-5377.1980.tb131845.x

Excipients in Anesthesia Medications
"Dextrose-containing solutions pose a significant risk to patients allergic to corn. Dextrose used for IV fluids is prepared by the simple hydrolysis of cornstarch."
Burbridge, Mark A. MD; Jaffe, Richard A. MD, PhD Excipients in Anesthesia Medications, Anesthesia & Analgesia: May 2019 - Volume 128 - Issue 5 - p 891-900 doi: 10.1213/ANE.0000000000003302
https://journals.lww.com/anesthesia-analgesia/Fulltext/2019/05000/Excipients_in_Anesthesia_Medications.11.aspx

Severe Hyponatremia and Seizure From Peripheral Infusion of Norepinephrine Diluted in Dextrose 5% in Water: A Case Report
Alibhai, Nafeesa*; Detsky, Michael MD, MSHP†,‡; Wunsch, Hannah MD, MSc§,; Teja, Bijan MD, MBA,¶ Severe Hyponatremia and Seizure From Peripheral Infusion of Norepinephrine Diluted in Dextrose 5% in Water: A Case Report, A & A Practice: May 2021 - Volume 15 - Issue 5 - p e01479 doi: 10.1213/XAA.0000000000001479
https://journals.lww.com/aacr/Abstract/2021/05000/Severe_Hyponatremia_and_Seizure_From_Peripheral.15.aspx

Probable anaphylactic reaction to corn-derived dextrose solution
Guharoy SR, Barajas M. Probable anaphylactic reaction to corn-derived dextrose solution. Vet Hum Toxicol. 1991 Dec;33(6):609-10. PMID: 1808842
https://pubmed.ncbi.nlm.nih.gov/1808842/

Acute Hypotension After 50% Dextrose Injections
Saites, Victoria MD; Laudanski, Krzysztof MD, PhD Acute Hypotension After 50% Dextrose Injections, A & A Case Reports: May 15, 2016 - Volume 6 - Issue 10 - p 296-298 doi: 10.1213/XAA.0000000000000299
https://journals.lww.com/aacr/Abstract/2016/05150/Acute_Hypotension_After_50__Dextrose_Injections.3.aspx

The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity
Peng, T.J., Andersen, L.W., Saindon, B.Z. et al. The administration of dextrose during in-hospital cardiac arrest is associated with increased mortality and neurologic morbidity. Crit Care 19, 160 (2015).
https://doi.org/10.1186/s13054-015-0867-z

BCPharmacists, "Warning: corn-related allergens . . ."
http://library.bcpharmacists.org/6_Resources/6-7_ReadLinks/ReadLinks-MayJun2007.pdf


What are the sources that continue to propagate the false narrative of equating dextrose (corn sugar manufactured from allergenic cornstarch) with glucose (blood sugar naturally present in all living organisms that is necessary for their survival)?
 

Reminder:  Dextrose (corn sugar/D-glucose) is an FDA-approved “food additive” that is manufactured from allergenic cornstarch, 21CFR184.1857.  Dextrose is not naturally occurring, but is manufactured corn sugar.  Dextrose can never be “naturally present” in any other food product, and it can never be “naturally present” in mammals.  Dextrose (corn sugar manufactured from allergenic cornstarch/D-glucose) is NOT glucose (blood sugar naturally present in all living organisms that is essential for their survival).

American Heritage Dictionary
"The dextrorotatory form of glucose . . . naturally occurring form of glucose found in all organisms.  Also called dextroglucose."
https://www.ahdictionary.com/word/search.html?q=dextrose

Archer Daniels Midland Company (ADM), Ingredient Supplier
ADM is a "Member Company" of the Corn Refiners Association
My June 2, 2021 Email to ADM, sweeteners@adm.com, Re: Dextrose (Corn Sugar)
https://cornallergyadvocacyresources.blogspot.com/2021/06/my-june-2-2021-email-to-adm-re-dextrose.html

BBI Healthcare
“Dextrose is a form of glucose found in naturally occurring foods such as corn, fruits, and honey.”
https://www.liftglucose.com/what-is-the-difference-between-glucose-dextrose/

My September 18, 2020, Email to BBI Healthcare Re: Glucose (blood sugar) vs. Dextrose (corn sugar)
https://cornallergyadvocacyresources.blogspot.com/2020/09/my-september-18-2020-email-to-bbi.html

Cambridge Dictionary
"a form of glucose (= a type of sugar) that is found in fruits, honey, etc."
https://dictionary.cambridge.org/dictionary/english/dextrose

Cargill, Ingredient Supplier
Cargill is a "Member Company" of the Corn Refiners Association
"Dextrose is a sugar occurring widely in nature – in honey and many fruits for example. As a constituent of cellulose, starch and glycogen, it is found in all plants and animals and is also known as ‘grape sugar’ or ‘blood sugar’."
https://www.cargill.com/food-bev/emea/sweeteners/c-dex-dextrose

Collins Dictionary
"Dextrose is a natural form of sugar that is found in fruits, honey, and in the blood of animals."
https://www.collinsdictionary.com/dictionary/english/dextrose

definition.org
"The dextrorotatory form of glucose, C6H12O6·H2O, found naturally in animal and plant tissue and derived synthetically from starch. Also called dextroglucose."
https://definition.org/define/dextrose/

Encylopedia Britannica
"Glucose, also called dextrose . . ." [Should state “D-glucose,” NOT “glucose.”]
https://www.britannica.com/science/glucose

FDA
Even though the FDA is clearly aware that dextrose is corn sugar manufactured from cornstarch/D-glucose pursuant to 21CFR184.1857, the FDA is erroneously equating HFCS (also manufactured from cornstarch) with blood sugar naturally present in all living organisms (glucose) in 21CFR182.1866.
https://www.govinfo.gov/content/pkg/CFR-1996-title21-vol3/html/CFR-1996-title21-vol3-sec182-1866.htm 

The FDA is implying that consuming HFCS is essential for our survival! / Quora Surveys

https://cornallergyadvocacyresources.blogspot.com/2021/06/the-fda-is-implying-that-consuming-hfcs.html

Greatist
"Dextrose is what’s dubbed a “simple sugar” and is made from corn (plus sometimes other veggies)." [emphasis added]
https://greatist.com/health/dextrose

Livestrong.com
"Although dextrose is derived from plants . . ." [only derived from corn]
https://www.livestrong.com/article/274155-what-is-dextrose-in-food/

Macmillan Dictionary
"a type of sugar that is found in fruit"
https://www.macmillandictionary.com/us/dictionary/american/dextrose

Medical News Today
“Dextrose is a sugar that comes from corn and sometimes other plants. [emphasis added]
https://www.medicalnewstoday.com/articles/322243

Merriam-Webster
"technical : a kind of sugar found in fruits, plants, etc. : a form of glucose"
https://www.merriam-webster.com/dictionary/dextrose#h1

NIH National Library of Medicine
After the NIH National Library of Medicine told me in an email that corn sugar and blood sugar are "one and the same," I filed the following petition against them for "willful negligence."

Glucose (blood sugar) must NEVER be equated with dextrose (corn sugar manufactured from cornstarch).
[This petition does NOT solicit donations.]
PETITION: Defund the NIH National Library of Medicine for Willful Negligence
https://www.change.org/p/united-states-department-of-health-human-services-defund-the-nih-national-library-of-medicine-for-willful-negligence

My August 29, 2020, Email to the National Library of Medicine Re: Depositor-Supplied Synonyms in PubChem Documents; e.g., Grape Sugar
https://cornallergyadvocacyresources.blogspot.com/2020/08/august-29-2020-email-to-national.html

When I discovered conflicting molecular formulas between the FDA and the NIH National Library of Medicine, I wrote the following "Open Letter to the FDA."  This letter was distributed globally, and the following recipients have responded positively to my letter addressing the conflicting molecular formulas between these agencies..

My January 6, 2021, Open Letter to the FDA Re: Critical Difference Between Glucose (Blood Sugar) and D-Glucose (Corn Sugar/Dextrose)
https://cornallergyadvocacyresources.blogspot.com/2021/01/my-january-6-2021-open-letter-to-fda-re.html

Allergy Strong, Washington, DC, @allergystrong

American Association of Surgical Physician Assistants (AASPA), @SurgeryPA

Arkansas Department of Human Services, Little Rock, AR, @ARHumanServices

Baptist Health, Northeast, FL, @BaptistHealthJx

Biology Online, @BiologyOnline2

Health New England, Springfield, MA, @HNEinc

Holy Redeemer Health, Meadowbrook, PA, @RedeemerHealth

Janice L. Pelletier, MD, FAAP, Orono/Penobscot, ME, @DrJanPeds

Ohio State University College of Medicine, Columbus, OH, @OhioStateMed

Primary Care Progress, Boston, MA, @PCareProgress

Regulatory Affairs Professional Society, Rockville, MD, @RAPSorg

Society for Academic Emergency Medicine (SAEM), Des Plaines, IL, @SAEMonline [Retweeted]

St. Michael's Elite Hospital, Sugar Land, TX, @StMichaelsER

Stanford MedicineX, Stanford, CA, @StanfordMedX

University of Maryland Eastern Shore, Princess Anne, MD. @UMESNews

University of Pittsburgh School of Pharmacy, Pittsburgh, PA, @pittpharmacy

University of Saint Joseph, West Hartford, CT, @USJCT

Salt of the Earth
"Is Dextrose Bad for You? What You Should Know"
[Their critical lack of knowledge regarding dextrose in this article endangers the lives of corn-allergic citizens.]
https://www.saltpgh.com/is-dextrose-bad-for-you/

Vocabulary.com
“. . . an isomer of glucose that is found in honey and sweet fruits.”
https://www.vocabulary.com/dictionary/dextrose

Wikipedia: 

If the reader references "dextrose" on Wikipedia, the reader is erroneously redirected to "glucose."  Glucose (blood sugar naturally present in all living organisms) must never be equated with dextrose (corn sugar manufactured from cornstarch/D-glucose).  Wikipedia has been notified of this critical error.

Included in my petition against the NIH National Library of Medicine. 

“Wikipedia should never be a source of reference for any official government publications; however, the National Library of Medicine often cites Wikipedia.

The NIH National Library of Medicine cites Wikipedia 9 times in one publication, alone:
Is it usual and customary for government agencies to cite Wikipedia in official government publications?”
https://pubchem.ncbi.nlm.nih.gov/compound/Inositol#section=Wikipedia

This practice is considered "circular referencing" if one or more parties control the narrative.   

Wikipedia warns against citing their articles.

"Wikipedia:Wikipedia is not a reliable source"

"Wikipedia is not a reliable source for citations elsewhere on Wikipedia. Because it can be edited by anyone at any time, any information it contains at a particular time could be vandalism, a work in progress, or just plain wrong. Biographies of living persons, subjects that happen to be in the news, and politically or culturally contentious topics are especially vulnerable to these issues. Edits on Wikipedia that are in error are usually fixed after some time. However, because Wikipedia is a volunteer-run project, it cannot constantly monitor every contribution. There are many errors that remain unnoticed for hours, days, weeks, months, or even years. Therefore, Wikipedia should not be considered a definitive source in and of itself."
https://en.wikipedia.org/wiki/Wikipedia:Wikipedia_is_not_a_reliable_source#:~:text=Wikipedia%20can%20be%20edited%20by,progress%2C%20or%20just%20plain%20wrong.&text=Therefore%2C%20Wikipedia%20should%20not%20be,source%20in%20and%20of%20itself

Your Dictionary:
". . . the naturally occurring form of glucose found in all organisms."

"A right-handed form of glucose found in plants and animals and in human blood, and made by the hydrolysis of starch with acids or enzymes."
https://www.yourdictionary.com/dextrose#websters


What are the risks to corn-allergic patients of equating corn sugar manufactured from cornstarch (dextrose/D-glucose) with glucose (blood sugar naturally present in all living organisms)?

Even though dextrose (corn sugar/D-glucose)-containing IV solutions are clearly contraindicated for administration to corn-allergic patients in the package insert, too many clinicians claim that “No one can be allergic to dextrose, since it’s naturally present in our body.”  Corn-allergic patients should not be required to assume the responsibility of educating our clinicians to guarantee our safety.  

Since dextrose (corn sugar/D-glucose) is often the carbohydrate-of-choice utilized as a glucose (blood sugar)-elevating agent in some IV solutions, this is the reason these solutions are contraindicated for administration to corn-allergic patients in the package insert.


What are the risks to corn-allergic consumers of equating corn sugar manufactured from cornstarch (dextrose/D-glucose) with glucose (blood sugar naturally present in all living organisms)? 

Some food manufacturers/retailers are claiming their products are free from corn even though the product contains dextrose.  They are equating dextrose (corn sugar) with blood sugar naturally present in all living organisms (glucose).

Some food manufacturers/retailers are listing “glucose syrup” as an ingredient on their label, when the label should indicate “dextrose.” They are erroneously equating dextrose (corn sugar) with blood sugar naturally present in all living organisms (glucose).

Some food manufacturers/retailers are claiming that dextrose can be derived from sources other than corn; e.g., tapioca-derived dextrose, rice-derived dextrose, etc. [FALSE] The only source of dextrose is corn.

Confirmation that dextrose (corn sugar/D-glucose) is only derived from corn. Dextrin (usually derived from corn) may be derived from food products other than corn.
https://cornallergyadvocacyresources.blogspot.com/2020/12/confirmation-that-dextrose-corn-sugard.html

Confirmation that dextrose equivalent (DE), corn sugar/D-glucose, is only derived from corn.
https://www.austradeinc.com/products/sweeteners/


Corn allergy studies/statistics:

Corn allergies are NOT rare.  Corn is exempt from FDA labeling requirements; therefore, corn allergy reactions are categorized as “idiopathic,” which leads to suppression of corn allergy statistics. 

May 2, 2021

Sesame Allergy Support Groups = 6.8K Members
Corn Allergy Support Groups = 14.7K Members

Imagine if this article read: "Sesame: It's Everything"

“Corn: It's Everything.” Iowa Corn
[Note: Pharmaceuticals]
https://www.iowacorn.org/education/corn-its-everything/

1st Quarter, 2021, Corn Allergy Statistics

In one corn allergy group of 11,161 members, the growth in membership represents a 1,016.1% increase in corn allergies in the last 93 months with an average of 109.2 new members/month.
https://cornallergyadvocacyresources.blogspot.com/2017/04/corn-allergy-statistics-monthly.html

Published Corn Allergy Studies (“. . . Maize major allergen . . .”)
https://cornallergyadvocacyresources.blogspot.com/2017/05/published-corn-allergy-studies.html


Summary

For the safety of corn-allergic citizens, the practice of equating corn-derived sweeteners with blood sugar naturally present in all living organisms (glucose) must cease immediately.

 

 

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

 

Additional Reference:

Corn Allergy References, Surveys, Studies, Statistics, & Petitions
https://cornallergyadvocacyresources.blogspot.com/2018/04/corn-allergy-reference-links.html

 
June 15, 2021, Critical Update:

Emergency tweet to my global contacts:

The NIH, NLM, and NCBI are intentionally endangering the lives of corn-allergic citizens with their erroneous definition of dextrose in this PubChem document. Dextrose is corn sugar manufactured from allergenic cornstarch, 21CFR184.1857.
https://pubchem.ncbi.nlm.nih.gov/compound/Dextrose-monohydrate


June 30, 2021, Critical Update:

The FDA’s June 30, 2021, reply to my June 28, 2021, email requesting their contact telephone number to provide to our clinicians verifying that dextrose is corn sugar (NOT "naturally present" in humans)
https://cornallergyadvocacyresources.blogspot.com/2021/06/the-fdas-june-30-2021-reply-to-my-june.html 


July 3, 2021, Critical Update:

As of December 21, 2020, this was the description for D-Glucose in this PubChem document: [screenshot taken]

"A primary source of energy for living organisms.  It is naturally occurring and is found in fruits and other parts of plants in its free state.  It is used therapeutically in fluid and nutrient replacement."
https://pubchem.ncbi.nlm.nih.gov/compound/5793

As of July 3, 2021, this description for D-Glucose was removed, and has now been applied to L-Glucose. In addition, “corn sugar” was correctly added as a Depositor-Supplied Synonym for D-Glucose.
https://pubchem.ncbi.nlm.nih.gov/compound/10954115




Blog Post Reference:

Dextrose is corn sugar, 21CFR184.1857, and can prove fatal to anyone with an IgE-mediated allergy to corn.
https://cornallergyadvocacyresources.blogspot.com/2021/06/dextrose-is-corn-sugar-21cfr1841857-and.html 

 

 

 

 

 

 


The intentional endangerment of corn-allergic citizens by U.S. regulatory agencies. [DOCUMENTED]

I was diagnosed with an IgE-mediated allergy to corn in 2011, and have been a full-time corn allergy advocate/researcher since 2014. My pu...