August 29, 2020, Email to the National Library of Medicine Re: Depositor-Supplied Synonyms in PubChem Documents; e.g., Grape Sugar

What standards does the NIH National Library of Medicine apply to "Depositor-Supplied Synonyms" in PubChem documents?  Let's use "grape sugar" as an example.

A quick search on Google for grape sugar has numerous erroneous and legitimate definitions for the source of this sugar.  It appears that the National Library of Medicine has opted for using the erroneous definitions for inclusion in PubChem documents.

CRITICAL REMINDER:  It is impossible for dextrose (corn sugar manufactured from cornstarch) to be found naturally in any food/drug/biologic product.  Dextrose is corn sugar that is ADDED TO these products.  Therefore, it is impossible for corn sugar (dextrose) to be naturally present in grapes/grape sugar.

Does the public have the right to request the "source" of the "Depositor-Supplied Synonym" from the National Library of Medicine for "grape sugar" that is listed in PubChem CID 79025?

https://pubchem.ncbi.nlm.nih.gov/compound/79025#section=Depositor-Supplied-Synonyms

I have personally supplied the National Library of Medicine with the Code of Federal Regulation 21CFR184.1857 which documents that dextrose is corn sugar. However, corn sugar is not included in the list of "Depositor-Supplied Synonyms" on either PubChem CID 79025 or PubChem CID 66370.

https://pubchem.ncbi.nlm.nih.gov/compound/79025#section=Depositor-Supplied-Synonyms

https://pubchem.ncbi.nlm.nih.gov/compound/Dextrose#section=Synonyms

Conclusion:

Based on this documentation, it is my personal opinion that the National Library of Medicine is complicit in propagating the false narrative about the source of dextrose (corn sugar manufactured from cornstarch) on behalf of the corn industry with no regard for the safety of corn-allergic consumers and patients.

Diane H. Corn Allergy Advocate

Corn Allergy Advocacy/Resources

https://cornallergyadvocacyresources.blogspot.com/

Email:  cornallergyinitiative@gmail.com

Twitter:  @CornAllergy911

References:

CORN SUGAR (DEXTROSE), CODE OF FEDERAL REGULATION 21CFR184.1857

https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

Dextrose: Facts vs. Fiction

https://cornallergyadvocacyresources.blogspot.com/2020/08/dextrose-facts-vs-fiction.html

Additional References

My August 29, 2020, Email to the FDA and the NIH National Library of Medicine Re: Immediate Revision of PubChem Documents Equating Glucose (Blood Sugar) with Dextrose (Corn Sugar)

https://cornallergyadvocacyresources.blogspot.com/2020/08/august-29-2020-email-to-fda-and-nih.html

My July 2, 2020, Appeal to the NIH National Library of Medicine Re: PubChem CID 79025, Glucose (Blood Sugar) vs. Dextrose (Corn Sugar Derived from Cornstarch)
https://cornallergyadvocacyresources.blogspot.com/2020/07/my-july-2-2020-appeal-to-nih-national.html

The NIH National Library of Medicine cites Wikipedia 9 times:
Is it usual and customary for government agencies to cite Wikipedia in official government publications?

https://pubchem.ncbi.nlm.nih.gov/compound/Inositol#section=DSSTox-Substance-ID

"Wikipedia:Wikipedia is not a reliable source"
https://en.wikipedia.org/wiki/Wikipedia:Wikipedia_is_not_a_reliable_source#:~:text=Wikipedia%20can%20be%20edited%20by,progress%2C%20or%20just%20plain%20wrong.&text=Therefore%2C%20Wikipedia%20should%20not%20be,source%20in%20and%20of%20itself.

Corn Allergy: A Potentially Life-Threatening Diagnosis

https://cornallergyadvocacyresources.blogspot.com/2020/01/corn-allergy-potentially-life.html

July, 2020, Month-End Corn Allergy Statistics: 949.9% Increase in 85 Months

(Corn is ubiquitous and is EXEMPT from FDA labeling requirements, resulting in underreporting and suppression of corn allergy statistics).

https://cornallergyadvocacyresources.blogspot.com/2017/04/corn-allergy-statistics-monthly.html

Corn Allergy References, Surveys, Studies, Statistics, & Petitions

(Includes my submission to The Joint Commission, Congress, FDA, & U.S. Dept. of Health requesting emergency mandate that hospitals stock corn-free foods, liquids, & drugs.)

https://cornallergyadvocacyresources.blogspot.com/2018/04/corn-allergy-reference-links.html

Blog Post Reference:

August 29, 2020, Email to the National Library of Medicine Re: Depositor-Supplied Synonyms in PubChem Documents; e.g., Grape Sugar

https://cornallergyadvocacyresources.blogspot.com/2020/08/august-29-2020-email-to-national.html

August 29, 2020, Email to the FDA and the NIH National Library of Medicine Re: Immediate Revision of PubChem Documents Equating Glucose (Blood Sugar) with Dextrose (Corn Sugar)

Numerous online publications erroneously claim that glucose (blood sugar) and dextrose (corn sugar) [1] are identical (or nearly identical), thereby endangering the lives of corn-allergic consumers and patients. [2-7]  The molecular weights of the following two compounds are not identical.  Therefore, which one of these molecular formulas represents straight blood sugar (glucose): the "main sugar that the body manufactures [and] serves as the major source of energy for living cells?” [8] It is clear that the definition of glucose (blood sugar) by Dr. William C. Shiel, Jr. supports the fact that glucose (blood sugar) cannot be equated with corn sugar manufactured from cornstarch (dextrose), since our body does not manufacture corn sugar (dextrose).

Re: PubChem CID 79025, alpha-D-Glucose

The Molecular Formula, C6H12O6, is a corn sugar (dextrose) formulation; and has a Molecular Weight of 180.16 g/mol.

https://pubchem.ncbi.nlm.nih.gov/compound/79025

Re: PubChem CID 66370, Dextrose

The Molecular Formula, C6H14O7, is also a corn sugar (dextrose) formulation; and has a Molecular Weight of 198.17 g/mol.

https://pubchem.ncbi.nlm.nih.gov/compound/Dextrose

Why is this Determination Critical?

In our corn allergy support groups of over 12K members, personal testimonies reveal that the majority of medical professionals are not aware that dextrose is corn sugar manufactured from cornstarch which can prove fatal to anyone with an IgE-mediated allergy to corn.  It is for this reason that intravenous fluids to which corn sugar (dextrose) has been added are contraindicated for administration to corn-allergic patients. [9] These medical professionals are erroneously equating glucose (blood sugar) with dextrose (corn sugar), thereby endangering the lives of corn-allergic patients.

One physician actually told a corn-allergic patient that “No one can be allergic to dextrose,” and proceeded to administer corn sugar (dextrose) IV fluid to this patient in direct violation of the contraindication warning in the package insert, which resulted in a severe allergic reaction requiring emergency intervention.  As a result of this testimony, and many other similar reports by our members, it took me three years to forward corn allergy documentation to the majority of our nation’s hospitals, colleges of medicine, and colleges of pharmacy.

Even after this monumental effort for the safety of corn-allergic patients, it is apparent that the majority of medical professionals remain oblivious to the danger of corn sugar (dextrose) for patients with an IgE-mediated allergy to corn.  Only recently, it was reported that a physician told a corn-allergic patient that “No one can be allergic to dextrose, since dextrose is naturally present in our bodies.”  He then administered the dextrose-containing IV fluid to this patient resulting in an anaphylactic reaction requiring emergency intervention.

Conclusion:

The contention that glucose (blood sugar) and dextrose (corn sugar) are “identical” is a false narrative which appears to have been initiated by the corn industry decades ago; [10] and endangers the lives of corn-allergic patients and consumers; e.g., some food manufacturers claim their products are corn free even though the product contains dextrose (corn sugar).

Immediate Revision is Required:

This false narrative may never have been revealed without Facebook, which provides a platform for addressing specific and non-specific IgE-mediated allergies through allergy support groups; e.g., these allergy support groups have revealed that, based on membership, corn allergies are more than twice as prevalent as sesame seed allergies. 

Now that this false narrative has been exposed, we are demanding that the NIH National Library of Medicine issue an immediate revision clarifying that these two distinct forms of sugar (one natural; one manufactured from cornstarch) are not identical. [11]

This critical correction will undoubtedly result in the required revision of many published papers; however, protecting the lives of corn-allergic consumers and patients should be your top priority.

Thank you for your immediate attention to this critical concern. 

Diane H., Corn Allergy Advocate

Corn Allergy Advocacy/Resources

https://cornallergyadvocacyresources.blogspot.com/

Email:  cornallergyinitiative@gmail.com

Twitter:  @CornAllergy911

References:

[1] CORN SUGAR (DEXTROSE), CODE OF FEDERAL REGULATION 21CFR184.1857

https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

[2] "D-glucose is often referred to as Dextrose or Dextro, they are one and the same and are biochemically identical to the glucose are bodies need."

https://www.liftglucose.com/what-is-the-difference-between-glucose-dextrose/#:~:text=D%2Dglucose%20is%20often%20referred,the%20glucose%20are%20bodies%20need.

[3] "Glucose is the sugar in blood, and dextrose is the name given to glucose produced from corn. Biochemically they are identical."

https://www.goodhousekeeping.com/food-recipes/healthy/a18910/types-of-sugar-0921/

[4] "Glucose and dextrose are almost the same (emphasis added). But these terms are different when considering their chemical structures; glucose molecules can be found in both D-glucose form and L-glucose form but, the term dextrose is used only for D-glucose molecules. Thus, the main difference between glucose and dextrose is that glucose includes both D-form and L-form whereas dextrose includes only the D-form of glucose.” (emphasis added)

https://pediaa.com/difference-between-glucose-and-dextrose/

[5] "Overall, although both has the same chemical formula (emphasis added) and are simple monosaccharides (sugars) glucose and dextrose still differ . . .” (emphasis added)

http://www.differencebetween.net/science/difference-between-glucose-and-dextrose/

[6] "Glucose and Dextrose are biochemically identical."

https://ingredi.com/blog/whats-the-difference-between-dextrose-and-table-sugar/

[7] "Dextrose (chemically identical to glucose) . . ."

https://opentextbc.ca/ingredients/chapter/glucosedextrose/

[8] William C. Shiel, Jr., MD, FACP, FACR, Medical Definition of Glucose, MedicineNet

https://www.medicinenet.com/script/main/art.asp?articlekey=3608

[9] CORN SUGAR (DEXTROSE) IV FLUIDS CONTRAINDICATED FOR CORN-ALLERGIC PATIENTS

https://cornallergyadvocacyresources.blogspot.com/2020/08/corn-sugar-dextrose-iv-fluids.html

[10] “Dextrose: All-American Corn Sugar,” Candy Professor, September 29, 2010

https://candyprofessor.com/2010/09/29/dextrose-all-american-corn-sugar/#:~:text=But%20by%201866%2C%20someone%20figured,dextrose%20from%20that%20corn%20starch

[11] Dextrose: Facts vs. Fiction

https://cornallergyadvocacyresources.blogspot.com/2020/08/dextrose-facts-vs-fiction.html

Additional References

My August 29, 2020, Email to the National Library of Medicine Re: Depositor-Supplied Synonyms in PubChem Documents; e.g., Grape Sugar

https://cornallergyadvocacyresources.blogspot.com/2020/08/august-29-2020-email-to-national.html

My July 2, 2020, Appeal to the NIH National Library of Medicine Re: PubChem CID 79025, Glucose (Blood Sugar) vs. Dextrose (Corn Sugar Derived from Cornstarch)

https://cornallergyadvocacyresources.blogspot.com/2020/07/my-july-2-2020-appeal-to-nih-national.html

Corn Allergy: A Potentially Life-Threatening Diagnosis

https://cornallergyadvocacyresources.blogspot.com/2020/01/corn-allergy-potentially-life.html

July, 2020, Month-End Corn Allergy Statistics: 949.9% Increase in 85 Months

(Corn is ubiquitous and is EXEMPT from FDA labeling requirements, resulting in underreporting and suppression of corn allergy statistics).

https://cornallergyadvocacyresources.blogspot.com/2017/04/corn-allergy-statistics-monthly.html

Corn Allergy References, Surveys, Studies, Statistics, & Petitions

(Includes my submission to The Joint Commission, Congress, FDA, & U.S. Dept. of Health requesting emergency mandate that hospitals stock corn-free foods, liquids, & drugs.)

https://cornallergyadvocacyresources.blogspot.com/2018/04/corn-allergy-reference-links.html

Blog Post Reference:

August 29, 2020, Email to the FDA and the NIH National Library of Medicine Re: Immediate Revision of PubChem Documents Equating Glucose (Blood Sugar) with Dextrose (Corn Sugar)

https://cornallergyadvocacyresources.blogspot.com/2020/08/august-29-2020-email-to-fda-and-nih.html

My August 26, 2020, Email to the FDA and the NIH National Library of Medicine Re: Molecular Formula for Glucose (Blood Sugar) vs. Dextrose (Corn Sugar)

Re: Case CAS-592684-L3B4Z2 - National Library of Medicine Customer Service confirmation TRACKING:000435000512147

Since I discovered that the National Library of Medicine references articles from Wikipedia, this has raised additional questions for factual information regarding pure blood sugar (glucose) vs. dextrose (corn sugar)

I may have discovered a possible false narrative, and I would like to know in what year dextrose (corn sugar manufactured from cornstarch) was first synthesized to be biochemically identical to pure blood sugar (glucose)?  Many publications (including my own blog) quote the same narrative that dextrose (corn sugar) and glucose (blood sugar) are biochemically identical (Molecular Formula C6H12O6).  However, it appears that this may not be factual.

Can you explain why dextrose (corn sugar) has a molecular formula of C6H1407?  This is not the same molecular formula of blood sugar, unless the molecular formula of pure blood sugar (glucose) is also C6H1407.

Dextrose PubChem 66370, Dextrose, Molecular Formula C6H14O7

https://pubchem.ncbi.nlm.nih.gov/compound/66370

Dextrose is corn sugar pursuant to Code of Federal Regulation 21CFR184.1857

https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

This refers to corn sugar (dextrose), so you are stating that dextrose (corn sugar) is biochemically identical to dextrose (corn sugar)..
alpha-D-Glucose PubChem 79025, Molecular Formula C6H12O6
https://pubchem.ncbi.nlm.nih.gov/compound/79025

This is not "pure" blood sugar (glucose), but refers to dextrose (corn sugar). so you are stating that dextrose (corn sugar) is biochemically identical to dextrose (corn sugar)..

D-Glucose (Compound) PubChem 5793, Molecular Formula C6H12O6

https://pubchem.ncbi.nlm.nih.gov/compound/5793

Production of dextrose from starch
https://patents.google.com/patent/US3039936A/en

Question:

What is the actual molecular formula of pure blood sugar (glucose), which is not to be confused with dextrose (corn sugar); e.g., nothing that is designated with the letter "D" (which represents corn sugar, dextrose)? 

Thank you for your assistance.

Diane H., Corn Allergy Advocate

Corn Allergy Advocacy/Resources

https://cornallergyadvocacyresources.blogspot.com/

Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

References:

My July 2, 2020, Appeal to the NIH National Library of Medicine Re: PubChem CID 79025, Glucose (Blood Sugar) vs. Dextrose (Corn Sugar Derived from Cornstarch)

https://cornallergyadvocacyresources.blogspot.com/2020/07/my-july-2-2020-appeal-to-nih-national.html

Dextrose: Facts vs. Fiction

https://cornallergyadvocacyresources.blogspot.com/2020/08/dextrose-facts-vs-fiction.html

Blog Post Link:

My August 26, 2020, Email to the FDA and the NIH National Library of Medicine Re: Molecular Formula for Glucose (Blood Sugar) vs. Dextrose (Corn Sugar)

https://cornallergyadvocacyresources.blogspot.com/2020/08/my-august-26-2020-email-to-fda-and-nih.html

My August 25, 2020, Emails to the NIH National Library of Medicine Re: Ascorbic Acid vs. Vitamin C

CRITICAL UPDATE:  Since submitting my email to the NIH National Library of Medicine this afternoon, the FDA just changed their classification of ascorbic acid from "Chemical Preservatives" to "Nutrients."  They revised it 8/25/2020, but did not indicate the date of revision.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8013

They changed the URL reference for Subpart D to Subpart I.  This is the current link to Subpart D, which classifies ascorbic acid as “Chemical Preservatives.”
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.3013

Reference added 4:10 pm EST, August 25, 2020:

"Ascorbic acid is also an industrially produced commodity, with preparations from D-glucose [DEXTROSE (CORN SUGAR)] . . ." Due to the availability of synthetic sources of ascorbic acid, it has become the primary source of the substance for food handling and processing applications." (emphasis added)
https://www.ams.usda.gov/sites/default/files/media/AscorbicAcidTRFinal7172019.pdf

---------------------------------------------------------------------

Second Email submitted as 4:55 pm EST, August 25, 2020, CAS-592356-L5Z5D1

To:  NIH National Library of Medicine, pubmedcentral@ncbi.nlm.nih.gov, Case #CAS-592247-DOS4H6

Re: Correction to Publication

Corrections are required in an article: Covarrubias-Pinto A, Acuña AI, Beltrán FA, Torres-Díaz L, Castro MA. Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders. Int J Mol Sci. 2015 Nov 27;16(12):28194-217. doi: 10.3390/ijms161226095. PMID: 26633354; PMCID: PMC4691042
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691042/

The United States Department of Agriculture classifies ascorbic acid as follows:

“Ascorbic acid is also an industrially produced commodity, with preparations from D-glucose [DEXTROSE (CORN SUGAR)] . . ." Due to the availability of synthetic sources of ascorbic acid, it has become the primary source (emphasis added) of the substance for food handling and processing applications.

https://www.ams.usda.gov/sites/default/files/media/AscorbicAcidTRFinal7172019.pdf

The FDA classifies Corn Sugar as Dextrose (D-glucose), Code of Federal Regulation 21CFR184.1857

“Corn sugar (C6H12O6, CAS Reg. No. 50-99-7), commonly called D-glucose or dextrose, is the chemical [alpha]-D-glucopyranose. It occurs as the anhydrous or the monohydrate form and is produced by the complete hydrolysis of corn starch . . .”

https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

Throughout this article, the term "ascorbic acid" needs to be replaced with "Vitamin C."

Examples of the misuse of the term "ascorbic acid" in this article.

1.  "Ascorbic acid . . . is an essential metabolite for a variety of organisms."
Rebuttal:  Corn sugar (dextrose) is not "an essential metabolite for a variety of organisms."

2.  "It is present in multiple fruits and vegetables."
Rebuttal:  It is impossible for corn sugar (dextrose) to be found naturally in any food products.

3.  ". . . is also synthesized from glucose in the liver . . ."
Rebuttal:  Corn sugar (dextrose) is not synthesized from glucose in the liver.

4. "Ascorbic acid is an important antioxidant with multiple cellular functions."
Rebuttal:  Corn sugar (dextrose) is not an antioxidant.

5. "Ascorbic acid is concentrated in the brain."
Rebuttal:  Corn sugar (dextrose) is not found in the brain of any living organism.


In summary, this article, as written, can endanger the lives of individuals with an IgE-mediated allergy to corn; since ascorbic acid primarily sourced from corn sugar (dextrose) is being equated with naturally-occurring Vitamin C.

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/

Email:  cornallergyinitiative@gmail.com

Twitter:  @CornAllergy911

---------------------------------------------------------------

First Email Submitted August 25, 2020 Case #CAS-592247-DOS4H6

To:  NIH National Library of Medicine, pubmedcentral@ncbi.nlm.nih.gov, Case #CAS-592247-DOS4H6

Re: Correction to Publication

Corrections are required in an article: Covarrubias-Pinto A, Acuña AI, Beltrán FA, Torres-Díaz L, Castro MA. Old Things New View: Ascorbic Acid Protects the Brain in Neurodegenerative Disorders. Int J Mol Sci. 2015 Nov 27;16(12):28194-217. doi: 10.3390/ijms161226095. PMID: 26633354; PMCID: PMC4691042
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691042/

Pursuant to Code of Federal Regulation 21CFR182.3013, Subpart D, ascorbic acid is clearly defined as a "chemical preservative." Ascorbic acid may be considered a synthetic version of Vitamin C; but it is not Vitamin C.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8013

Throughout this article, the term "ascorbic acid" needs to be replaced with "Vitamin C."

Examples of the misuse of the term "ascorbic acid" in this article.

1.  "Ascorbic acid . . . is an essential metabolite for a variety of organisms."
Rebuttal:  This chemical preservative is not "an essential metabolite for a variety of organisms."

2.  "It is present in multiple fruits and vegetables."
Rebuttal:  It is impossible for this chemical preservative to be found naturally in any food products.

3.  ". . . is also synthesized from glucose in the liver . . ."
Rebuttal:  This chemical preservative is not synthesized from glucose in the liver.

4. "Ascorbic acid is an important antioxidant with multiple cellular functions."
Rebuttal:  This chemical preservative is not an antioxidant.

5. "Ascorbic acid is concentrated in the brain."
Rebuttal:  This chemical preservative is not found in the brain of any living organism.

Personal certification:  I am not allergic to Vitamin C, but am highly allergic to ascorbic acid that is used as a chemical preservative in many food products such as fruit juices.  This is due to the fact that most ascorbic acid is derived from corn, and I have an IgE-mediated allergy to corn.

In summary, this article, as written, can endanger the lives of individuals with an IgE-mediated allergy to corn; since ascorbic acid (a chemical preservative usually derived from corn) is being equated with naturally-occurring Vitamin C.


Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

Blog post link:

My August 25, 2020, Emails to the NIH National Library of Medicine Re: Ascorbic Acid vs. Vitamin C

https://cornallergyadvocacyresources.blogspot.com/2020/08/my-august-25-2020-emails-to-nih.html

Dextrose (Corn Sugar/D-Glucose) IV Solutions Contraindicated for Administration to Corn-Allergic Patients

[Updated January 24, 2021]

Dextrose (D-glucose) is corn sugar “produced by the complete hydrolysis of corn starch [sic] with safe and suitable acids or enzymes, followed by refinement and crystallization from the resulting hydrolysate.” [1,2]  Therefore, IV solutions to which corn sugar (dextrose/D-glucose) has been added are clearly contraindicated for administration to corn-allergic patients in the package insert. [3-7]  Anaphylactic reactions to dextrose (corn sugar/D-glucose) IV fluids have been documented in published literature. [8,9]

Administering dextrose (corn sugar/D-glucose)-containing drug/biologic products to corn-allergic patients is a critical medical error equivalent to administering penicillin to patients with an allergy to penicillin.  Based upon the personal testimonies from the 16K+ members in our corn allergy support groups that many clinicians are also unaware of this critical contraindication warning, we have issued guidelines for reporting medical professionals who administer dextrose (D-glucose/corn sugar)-containing IV solutions to corn-allergic patients in direct violation of the contraindication warning in the package insert. [10]  

Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911

References

[1] United States Food & Drug Administration. (2019, April 1). Code of Federal Regulations Title 21, Volume 3, 21CFR184.1857, Section 184.1857 Corn Sugar, United States Department of Health & Human Services
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857

[2]  "Corn must first be converted to corn sugar (dextrose, the common commercial name for D-glucose) . . ." [emphasis added]
https://polymerinnovationblog.com/from-corn-to-poly-lactic-acid-pla-fermentation-in-action/

[3] LACTATED RINGERS IN 5% DEXTROSE
Generic Name: lactated ringer's and 5% dextrose injection
Brand Name: Lactated Ringer's in 5% Dextrose

CONTRAINDICATIONS
“Solutions containing dextrose may be contraindicated in patients with known allergy to corn or corn products.” (emphasis added)
https://www.rxlist.com/lactated-ringers-in-5-dextrose-drug.htm

[4] Lactated Ringer’s and 5% Dextrose Injection, USP in VIAFLEX Plastic Container
“Dextrose is derived from corn.” (emphasis added)
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6acc9f96-7088-45a7-b48f-1a861e3467ab&type=display

[5] LABEL: DEXTROSE IN LACTATED RINGERS- dextrose, sodium chloride, sodium lactate, potassium chloride, and calcium chloride injection, solution 

CONTRAINDICATIONS
“Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products.” (emphasis added)
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=190da07e-a616-46e6-b4e5-1c0ba39306e5

[6] DEXTROSE IN LACTATED RINGERS- dextrose, sodium chloride, sodium lactate, potassium chloride, and calcium chloride injection, solution

B. Braun Medical Inc.

----------

5% Dextrose in Lactated Ringer's Injection
“Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products.” (emphasis added)
https://rxdruglabels.com/lib/rx/rx-meds/dextrose-in-lactated-ringers-1/

[7] Baxter Lactated Ringer’s and 5% Dextrose Injection, USP

WARNINGS
“Solutions containing dextrose should be used with caution, if at all, in patients with known allergy to corn or corn products.”(emphasis added)
https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf

[8] Guharoy SR, Barajas M. Probable anaphylactic reaction to corn-derived dextrose solution. Vet Hum Toxicol. 1991;33(6):609-610.
https://pubmed.ncbi.nlm.nih.gov/1808842/

[9] College of Pharmacists of British Columbia, Warning: corn-related allergens,
Non-medicinal ingredients don’t appear on drug labels, ReadLinks, May/June 2007, Vol. 32, No. 3
http://library.bcpharmacists.org/6_Resources/6-7_ReadLinks/ReadLinks-MayJun2007.pdf

[10] Guidelines for reporting medical professionals who administer corn sugar (dextrose/D-glucose) IV fluids to corn-allergic patients in direct violation of the contraindication warning in the package insert.
LACTATED RINGER’S IN 5% DEXTROSE CONTRAINDICATED FOR CORN-ALLERGIC PATIENTS
https://cornallergyadvocacyresources.blogspot.com/2019/12/lactated-ringers-in-5-dextrose.html

Additional Reference

Corn Allergy References, Surveys, Studies (“. . . Maize major allergen . . .”), Statistics, & Petitions
https://cornallergyadvocacyresources.blogspot.com/2018/04/corn-allergy-reference-links.html


Blog Post Reference:

Dextrose (Corn Sugar/D-Glucose) IV Solutions Contraindicated for Administration to Corn-Allergic Patients
https://cornallergyadvocacyresources.blogspot.com/2020/08/corn-sugar-dextrose-iv-fluids.html

Dextrose: Facts vs. Fiction

Dextrose is corn sugar, 21CFR184.1857, and can prove fatal to anyone with an IgE-mediated allergy to corn.
https://cornallergyadvocacyresources.blogspot.com/2021/06/dextrose-is-corn-sugar-21cfr1841857-and.html

Diane H., Corn Allergy Advocate

Corn Allergy Advocacy/Resources

https://cornallergyadvocacyresources.blogspot.com/

Email:  cornallergyinitiative@gmail.com
Twitter:  @CornAllergy911