Since
sending this email to the FDA and the NIH National Library of Medicine,
Rxlist.com has revised their definition of dextrose (corn sugar manufactured
from cornstarch, 21CFR184.1857) from a "glucose-elevating agent" to an
"antidote" with no contraindication warning for administration to
corn-allergic patients. This revised
definition of dextrose not only endangers
the lives of corn-allergic patients, but also exposes physicians to potential liability if they
prescribe/administer dextrose-containing drug/biologic products to
corn-allergic patients, even though no contraindication warning is indicated in
the package insert. Dextrose (corn sugar) is, in fact, a blood sugar (glucose)-elevating
agent.
To: NLM
Support, nlm-support@nlm.nih.gov
NLM Communications, NLMCommunications@nlm.nih.gov
PubChem Central, pubmedcentral@ncbi.nlm.nih.gov
CDER DRUG INFO, druginfo@fda.hhs.gov
Dextrose is a "Glucose-Elevating Agent" - Rxlist.com
Since dextrose (corn sugar manufactured
from cornstarch) is a "glucose-elevating agent," how can these two
distinct forms of sugar have the same molecular formula?
Dextrose is a "Glucose-Elevating Agent."
https://www.rxlist.com/consumer_dextrose/drugs-condition.htm
Dextrose Molecular
Formula C6H14O7
PubChem CID: 66370
https://pubchem.ncbi.nlm.nih.gov/compound/DEXTROSE
Corn Syrup Molecular Formula C6H14O7
PubChem CID: 5282499
https://pubchem.ncbi.nlm.nih.gov/compound/Corn-syrup
Cornstarch Molecular
Formula C27H48O20
PubChem CID: 24836924
https://pubchem.ncbi.nlm.nih.gov/compound/24836924
Therefore, how can corn sugar manufactured from cornstarch be assigned molecular
formula C6H12O6?
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=184.1857
Again, how can corn sugar and blood sugar be "one and the same," particularly since blood sugar found naturally in all living organisms (glucose) cannot provoke an allergic response; whereas, corn sugar manufactured from cornstarch (dextrose) can prove fatal to anyone with an IgE-mediated allergy to corn?
In my interview with my primary care
physician on September 30, 2020, he could not answer this question. In
addition, he admitted that he did not know that dextrose is corn sugar
manufactured from cornstarch; and was unaware that IV fluids to which corn
sugar (dextrose) has been added are contraindicated for administration to corn-allergic patients in the package insert.
Since this could result in a liability issue for physicians, I have been
forwarding this critical documentation to medical
malpractice insurers. It took me three years to forward the package
insert accompanying dextrose IV solutions to our nation's hospitals, colleges
of medicine, and colleges of pharmacy; however, we continue to receive reports from
the 12K+ members in our corn allergy support groups that the contraindication
warning is being ignored by medical staff. It is my hope that medical
malpractice insurers will also forward this critical information not only to
protect medical professionals from potential liability, but also for the
protection of corn-allergic patients from this critical medical error.
In the meantime, I have shared the following blog post with corn allergy group members in addition to applicable global contacts; e.g., European Union and Canadian hospitals/agencies, etc.
Guidelines for
reporting medical professionals who administer corn sugar (dextrose) IV fluids
to corn-allergic patients in direct violation of the contraindication warning
in the package insert.
LACTATED RINGER’S IN 5% DEXTROSE
CONTRAINDICATED FOR CORN-ALLERGIC PATIENTS
https://cornallergyadvocacyresources.blogspot.com/2019/12/lactated-ringers-in-5-dextrose.html
Thank you for your attention to this critical concern.
Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email:
cornallergyinitiative@gmail.com
Twitter: @CornAllergy911
My September 29,
2020, Email to Baxter Healthcare Ltd Re: Dextrose IV Fluid
https://cornallergyadvocacyresources.blogspot.com/2020/09/my-september-29-2020-email-to-baxter.html
Blog Post Reference Link:
My October 7, 2020, Email to the FDA and NIH National
Library of Medicine Re: Dextrose IV Fluids
https://cornallergyadvocacyresources.blogspot.com/2020/10/my-october-7-2020-email-to-fda-and-nih.html
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