CRITICAL UPDATE: Since submitting my email to the NIH National Library
of Medicine this afternoon, the FDA just changed their classification of
ascorbic acid from "Chemical Preservatives" to
"Nutrients." They revised it 8/25/2020, but did not indicate
the date of revision.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8013
They changed the URL reference for Subpart D to Subpart I. This is the current link to Subpart D, which classifies ascorbic acid as “Chemical Preservatives.”
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.3013
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8013
They changed the URL reference for Subpart D to Subpart I. This is the current link to Subpart D, which classifies ascorbic acid as “Chemical Preservatives.”
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.3013
Reference added 4:10 pm EST, August 25, 2020:
"Ascorbic acid is also an
industrially produced commodity, with preparations from D-glucose [DEXTROSE
(CORN SUGAR)] . . ." Due to the availability of synthetic sources
of ascorbic acid, it has become the primary source of the substance for food
handling and processing applications." (emphasis added)
https://www.ams.usda.gov/sites/default/files/media/AscorbicAcidTRFinal7172019.pdf
https://www.ams.usda.gov/sites/default/files/media/AscorbicAcidTRFinal7172019.pdf
Second Email
submitted as 4:55 pm EST, August 25, 2020, CAS-592356-L5Z5D1
Re:
Correction to Publication
Corrections are required in an article: Covarrubias-Pinto A,
Acuña AI, Beltrán FA, Torres-Díaz L, Castro MA. Old Things New View: Ascorbic
Acid Protects the Brain in Neurodegenerative Disorders. Int J Mol Sci. 2015 Nov
27;16(12):28194-217. doi: 10.3390/ijms161226095. PMID: 26633354; PMCID:
PMC4691042
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691042/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691042/
The United States
Department of Agriculture classifies ascorbic acid as follows:
“Ascorbic acid is also an industrially produced commodity, with preparations from D-glucose [DEXTROSE (CORN SUGAR)] . . ." Due to the availability of synthetic sources of ascorbic acid, it has become the primary source (emphasis added) of the substance for food handling and processing applications.
“Ascorbic acid is also an industrially produced commodity, with preparations from D-glucose [DEXTROSE (CORN SUGAR)] . . ." Due to the availability of synthetic sources of ascorbic acid, it has become the primary source (emphasis added) of the substance for food handling and processing applications.
The FDA classifies
Corn Sugar as Dextrose (D-glucose), Code of Federal Regulation 21CFR184.1857
“Corn sugar (C6H12O6, CAS Reg. No. 50-99-7), commonly called
D-glucose or dextrose, is the chemical [alpha]-D-glucopyranose. It occurs as
the anhydrous or the monohydrate form and is produced by the complete
hydrolysis of corn starch . . .”
Throughout this article, the term "ascorbic acid"
needs to be replaced with "Vitamin C."
Examples of the misuse of the term "ascorbic acid" in this article.
1. "Ascorbic acid . . . is an essential metabolite for a variety of organisms."
Rebuttal: Corn sugar (dextrose) is not "an essential metabolite for a variety of organisms."
2. "It is present in multiple fruits and vegetables."
Rebuttal: It is impossible for corn sugar (dextrose) to be found naturally in any food products.
3. ". . . is also synthesized from glucose in the liver . . ."
Rebuttal: Corn sugar (dextrose) is not synthesized from glucose in the liver.
4. "Ascorbic acid is an important antioxidant with multiple cellular functions."
Rebuttal: Corn sugar (dextrose) is not an antioxidant.
5. "Ascorbic acid is concentrated in the brain."
Rebuttal: Corn sugar (dextrose) is not found in the brain of any living organism.
In summary, this article, as written, can endanger the lives of individuals with an IgE-mediated allergy to corn; since ascorbic acid primarily sourced from corn sugar (dextrose) is being equated with naturally-occurring Vitamin C.
Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Twitter: @CornAllergy911Examples of the misuse of the term "ascorbic acid" in this article.
1. "Ascorbic acid . . . is an essential metabolite for a variety of organisms."
Rebuttal: Corn sugar (dextrose) is not "an essential metabolite for a variety of organisms."
2. "It is present in multiple fruits and vegetables."
Rebuttal: It is impossible for corn sugar (dextrose) to be found naturally in any food products.
3. ". . . is also synthesized from glucose in the liver . . ."
Rebuttal: Corn sugar (dextrose) is not synthesized from glucose in the liver.
4. "Ascorbic acid is an important antioxidant with multiple cellular functions."
Rebuttal: Corn sugar (dextrose) is not an antioxidant.
5. "Ascorbic acid is concentrated in the brain."
Rebuttal: Corn sugar (dextrose) is not found in the brain of any living organism.
In summary, this article, as written, can endanger the lives of individuals with an IgE-mediated allergy to corn; since ascorbic acid primarily sourced from corn sugar (dextrose) is being equated with naturally-occurring Vitamin C.
Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
---------------------------------------------------------------
First Email
Submitted August 25, 2020 Case #CAS-592247-DOS4H6
Re:
Correction to Publication
Corrections
are required in an article: Covarrubias-Pinto A, Acuña AI, Beltrán FA,
Torres-Díaz L, Castro MA. Old Things New View: Ascorbic Acid Protects the Brain
in Neurodegenerative Disorders. Int J Mol Sci. 2015 Nov 27;16(12):28194-217.
doi: 10.3390/ijms161226095. PMID: 26633354; PMCID: PMC4691042
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691042/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4691042/
Pursuant
to Code of Federal Regulation 21CFR182.3013, Subpart D, ascorbic acid is
clearly defined as a "chemical preservative." Ascorbic acid may be
considered a synthetic version of Vitamin C; but it is not Vitamin C.
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8013
https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=182.8013
Throughout
this article, the term "ascorbic acid" needs to be replaced with
"Vitamin C."
Examples of the misuse of the term "ascorbic acid" in this article.
1. "Ascorbic acid . . . is an essential metabolite for a variety of organisms."
Rebuttal: This chemical preservative is not "an essential metabolite for a variety of organisms."
2. "It is present in multiple fruits and vegetables."
Rebuttal: It is impossible for this chemical preservative to be found naturally in any food products.
3. ". . . is also synthesized from glucose in the liver . . ."
Rebuttal: This chemical preservative is not synthesized from glucose in the liver.
4. "Ascorbic acid is an important antioxidant with multiple cellular functions."
Rebuttal: This chemical preservative is not an antioxidant.
5. "Ascorbic acid is concentrated in the brain."
Rebuttal: This chemical preservative is not found in the brain of any living organism.
Personal certification: I am not allergic to Vitamin C, but am highly allergic to ascorbic acid that is used as a chemical preservative in many food products such as fruit juices. This is due to the fact that most ascorbic acid is derived from corn, and I have an IgE-mediated allergy to corn.
In summary, this article, as written, can endanger the lives of individuals with an IgE-mediated allergy to corn; since ascorbic acid (a chemical preservative usually derived from corn) is being equated with naturally-occurring Vitamin C.
Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email: cornallergyinitiative@gmail.com
Twitter: @CornAllergy911
Examples of the misuse of the term "ascorbic acid" in this article.
1. "Ascorbic acid . . . is an essential metabolite for a variety of organisms."
Rebuttal: This chemical preservative is not "an essential metabolite for a variety of organisms."
2. "It is present in multiple fruits and vegetables."
Rebuttal: It is impossible for this chemical preservative to be found naturally in any food products.
3. ". . . is also synthesized from glucose in the liver . . ."
Rebuttal: This chemical preservative is not synthesized from glucose in the liver.
4. "Ascorbic acid is an important antioxidant with multiple cellular functions."
Rebuttal: This chemical preservative is not an antioxidant.
5. "Ascorbic acid is concentrated in the brain."
Rebuttal: This chemical preservative is not found in the brain of any living organism.
Personal certification: I am not allergic to Vitamin C, but am highly allergic to ascorbic acid that is used as a chemical preservative in many food products such as fruit juices. This is due to the fact that most ascorbic acid is derived from corn, and I have an IgE-mediated allergy to corn.
In summary, this article, as written, can endanger the lives of individuals with an IgE-mediated allergy to corn; since ascorbic acid (a chemical preservative usually derived from corn) is being equated with naturally-occurring Vitamin C.
Diane H., Corn Allergy Advocate
Corn Allergy Advocacy/Resources
https://cornallergyadvocacyresources.blogspot.com/
Email: cornallergyinitiative@gmail.com
Twitter: @CornAllergy911
Blog post link:
My August 25, 2020, Emails to
the NIH National Library of Medicine Re: Ascorbic Acid vs. Vitamin C
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